MH Guide Labs

Evidence-Based Clinical Annotations

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MH Guide is an aid for diagnostic and pathology laboratories to identify genetic variant data from a patient's tumor specimen.

Benefits for Labs

Significant

MH Guide identifies variants based on the user-defined filter criteria. Trained users review the list of variants to determine the significant clinically-actionable variants based on medical interpretation of individual patient result. 

Easy installation

MH Guide is easy to access, operate, and maintain. Molecular Health also offers application hosting and data storage.

Certification

MH Guide is registered as an in vitro diagnostic medical device (IVD) in Europe, conforms with the applicable European regulation (CE marked), and fulfills legal and regulatory requirements on validation and privacy (CAP, CLIA, HIPAA, ISO).

Up to date

MH Guide software, tools, methods, algorithms, and data are constantly updated, tested, and validated. And MH Guide is continuously improved with regular software and data updates.

Clinical context

For clinical interpretation of molecular diagnostic data, you need to understand the genetic make-up of the patient in a clinical context. MH Guide can help you.

Fast

MH Guide initiates the bioinformatics pipeline automatically when recognizes newly uploaded data. A web-based graphical user interface enables trained users to review annotated clinical results and generate a customizable clinical report within one user interface.   

Flexible

We can process BAM or FASTQ files, as well as VCF files. And we can provide a case-specific clinical molecular record in the form of an XML file, or you can use an online interface to prepare clinical reports in PDF-format, customized to your specifications.

Traceable

Deep dive into information sources. MH Guide database contains expertly curated biomarkers of drug response, resistance, and toxicity, based on the world's biomedical literature and more than six million patient cases, allowing therapy options to be traced back to source.

Quality

We offer ethnicity-specific sequence analysis and can help you identify clinically relevant genomic aberrations. We compare these to biomarkers from the top global medical data sources and complete quality checks on all referenced biomarkers.

Scalable

Avoid interpretation bottlenecks. Our fully automated clinical, molecular, and pharmacologic workflows, fast VCF file interpretation, and web-based delivery of results mean we will always process cases efficiently.

Training

MH Guide comes with a full package of expert training and support to facilitate roll-out and implementation of the software in your organization.

Authoritative

MH Guide information is sourced from approved, canonical medical knowledge, providing an authoritative basis to aid trained medical experts, such as board certified Molecular Pathologists or Molecular Geneticist to make clinical decision based on the genetic data from the patient's tumor.

Comprehensive

MH Guide contextualizes patient-specific molecular data against global biomolecular knowledge.

Seamless integration into clinical routine practice through flexible interfaces

 
PATIENT SEQUENCE DATA AND DIAGNOSIS
FASTQ | VCF BAM+BED | ILLUMINA 
 
BIOINFORMATICS PIPELINE
TUMOR | NORMAL
 
KNOWLEDGE MINING
OBSERVED | PREDICTED
 
CLINICAL ANNOTATION
BIOMARKER | CASE
 
REPORTING / INTEGRATION
CLOUD | XML | PDF

Major components of MH Guide are:

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Automated clinical data interpretation based on Dataome knowledge base
Flexible clinico-molecular data output interface
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Our Dataome platform draws on the world's health knowledge

Molecular Health has built a comprehensive data warehouse that contains biomedical reference information of unique quality.