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Predisposition analyses of hereditary breast and ovarian cancer syndrome (HBOC)

MH Guide/BRCA: automated analysis of HBOC syndrome

MH Guide/BRCA is optimized for identifying and reporting clinically-significant germline variants associated with hereditary breast and ovarian cancer syndrome (HBOC). This application, a module of MH Guide, assists human genetics laboratories in assessing germline variants in BRCA1, BRCA2, and other HBOC-related genes.

Just like MH Guide, MH Guide/BRCA analyzes gene variants by comparing them with data from Dataome, one of the world’s largest knowledge bases of biomedical information. The software classifies variants through automated access to relevant databases and uses international scientific standards for variant classification. MH Guide/BRCA summarizes all of the relevant results in individual reports, giving users clear, specific indications of possible disease-causing genetic variations associated with HBOC.

“Ensure your variant analyses are always in line with the latest science, and benefit from an intuitive application that fits seamlessly into your lab routine: MH Guide/BRCA.”

Dr. Josef Hermanns
Head of Project Management

Identify predisposition to HBOC – quickly, accurately, and efficiently

MH Guide/BRCA identifies and classifies germline variants in BRCA1/2 or other HBOC-relevant genes. Human genetics laboratories benefit from efficient, highly-automated analyses that automatically identify HBOC-relevant gene variants and pre-classify them according to ACMG standards.

MH Guide/BRCA accesses publicly-available databases for variant interpretation (e.g. ClinVar, BRCA Exchange, UTAH BRCA) via Dataome and ensures that the data is updated regularly. Users can store their own variant classifications in the protected area of their account. HBOC analyses according to the current state of science and research are now possible.

How you can benefit from MH Guide/BRCA

Approved for diagnostic use
MH Guide/BRCA is a module of MH Guide, which is approved as an IVD medical device in the EU and intended for diagnostic use.

Faster results
Automatic access to relevant databases, as well as variant pre-classification according to ACMG criteria and genotype-phenotype correlations, help healthcare professionals identify HBOC-related variants faster, and generate patient reports efficiently.

Easy to integrate
MH Guide/BRCA is a web-based application that can be immediately integrated into your lab routine. In addition, flexible interfaces make it possible to analyze standard data formats from the sequencing of commercially-available or proprietary gene panels, independent of the platform used.

Customizable analysis
MH Guide/BRCA is optimized for use in clinical routine. The filtering and editing options within the software allow quick access to the most important information.

Audited quality
Molecular Health is committed to meeting strict international standards – and is certified to EN ISO 13485. Users benefit from maximum safety and reliability.

Flexibility and data security in one

The web-based software application MH Guide/BRCA can be easily integrated in the laboratory. It enables the annotation and interpretation of genetic variants from common NGS or other analysis platforms. The software allows users to generate highly-automated individual patient reports, each of which can be expanded and refined. The software generates clear, customizable report templates in various formats (PDF, JSON, XML) and is compatible with VCF and FASTQ data formats.

MH Guide/BRCA meets the highest standards of data privacy, data security, as well as risk and quality management.

Approved for clinical use

MH Guide/BRCA is a module of MH Guide, a software application approved in Europe as an IVD medical device (according to Directive 98/79/EC).

SaaS – individually scalable

MH Guide/BRCA is offered as scalable SaaS (Software as a Service) to suit small and large institutions alike.

Customizable patient reports

The design, content, and format of analysis reports can be adapted to individual needs on request.

Flexible input and output formats

MH Guide/BRCA can process the standard data formats VCF and FASTQ. Output formats are PDF, JSON, and XML.

Secure data transmission

MH Guide/BRCA provides secure transmission of patient data through advanced encryption standards (SSL/TLS, AES-256) and storage of patient data with controlled access authorization.

Guaranteed security of patient data

MH Guide/BRCA complies with GDPR in Europe, GenDG in Germany, and the Health Insurance Portability and Accountability Act (HIPAA) in the USA.

Efficient workflows in your laboratory

MH Guide/BRCA lets you optimize your everyday processes. The cloud-based software automates the interpretation of germline variants and delivers high-quality analyses.

Intuitive report generation in just a few steps

MH Guide/BRCA intuitively guides users from data upload to final patient report.

1. Upload sequence data to the MH Order Portal – via your browser

MH BRCA - 1. MH Order Portal File Upload_Kontur

2. Automatic variant classification

MH BRCA -2. Preclassified variant_Kontur

3. Creation of the report

MH BRCA -3. Report Erstellung_Kontur

4. Export of the report

MH BRCA - Sample Report-1_Kontur

Dr. Katrin Stecker
Head of Scientific Field Support

“Want to know how you can benefit from MH Guide/BRCA? We’re happy to demonstrate the application or go through a specific case with you. Just get in touch.” 

FAQs

MH Guide/BRCA generates well-designed, adaptable report templates in various formats (PDF, JSON, XML) and can process FASTQ and VCF data formats.

MH Guide/BRCA, like MH Guide, fulfills the highest standards in terms of data privacy and data protection, as well as risk and quality management. Data sovereignty always lies with the user. Confidential patient data is transmitted using advanced encryption standards (SSL/TLS, AES-256).

This depends on your requirements. Prices are calculated based on the number of analyses and the size of the gene panels to be analyzed. We are happy to advise you personally.

MH Guide is the main software application, MH Guide/BRCA and MH Guide/Mendel are special modules. You can find more information here.

You can use any commercially available or proprietary gene panels (e.g. BRCA1/2 panels, HBOC risk gene panels) and have the data analyzed in VCF format with MH Guide/BRCA. Likewise, raw data (FASTQ) from many popular Illumina platforms can be analyzed.

On request, Molecular Health can assist you in transferring ACMG-compatible variant classifications from your own databases to your account.

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