Impressively reliable and fast

The future of hereditary disease diagnostics

Use worldwide knowledge to reliably determine the risk of genetic disease

MH Guide/Mendel is optimized for the evaluation of germline variants associated with hereditary diseases. The software application is a module of MH Guide and supports human geneticists in the evaluation of germline variants.

Just like MH Guide, MH Guide/Mendel analyzes gene variants in comparison with data from Dataome, one of the world’s largest databases of biomedical information. The software annotates variants through automated access to relevant databases and uses international standards for variant classification. MH Guide/Mendel summarizes all relevant results in individual reports that provide users with clear, specific information on possible disease-causing genetic variations associated with hereditary diseases.

“Ensure your variant analyses are always in line with the latest science, and benefit from an intuitive application that fits seamlessly into your lab routine: MH Guide/Mendel.” 

PhD Josef Hermanns
Director Project Office

Fast, precise assessment of germline variants

MH Guide/Mendel identifies, annotates, and classifies variants for hereditary diseases. The software automatically matches these with data from the comprehensive, regularly updated and quality-controlled database Dataome. This database includes the biomedical knowledge currently published on relevant hereditary diseases and disease-causing genetic variants.

The resulting report summarizes diagnostic information at a glance:

  • What are the functional effects of the variants?
  • To what hereditary diseases is the patient predisposed?
  • What hereditary diseases can be diagnosed based on the identified genetic variants?

How you can benefit from MH Guide/Mendel

Approved for diagnostic use
MH Guide/Mendel is a module of MH Guide, which is approved as an IVD medical device in the EU and intended for diagnostic use.

Faster results
By automatically accessing relevant databases and pre-classifying variants according to ACMG criteria, MH Guide/Mendel quickly and accurately identifies and annotates gene variants associated with hereditary diseases.

Customizable evaluation
MH Guide/Mendel is optimized for use in clinical routine. The filtering and editing options within the software allow quick access to the most important information. Users can store their own variant classifications in the protected area of their account.

Easy to integrate
MH Guide/Mendel is a web-based application that can be immediately integrated into your lab routine. In addition, flexible interfaces make it possible to analyze standard data formats from the sequencing of commercially-available or proprietary gene panels, independent of the platform used.

Scalable analysis process
The optimized workflow of MH Guide/Mendel enables rapid conversion at a high sample throughput.

Audited quality
Molecular Health is committed to strict international standards – and is certified to EN ISO 13485. Users benefit from maximum safety and reliability.

Flexibility and data security in one

The web-based software application MH Guide/Mendel can be easily integrated in the laboratory.

It enables the annotation and interpretation of genetic variants from common NGS or other analysis platforms. The software allows users to generate highly-automated individual patient reports, each of which can be expanded and refined. The application generates clear, customizable report templates in various formats (PDF, JSON, XML) and is compatible with VCF and FASTQ data formats.

MH Guide/Mendel meets the highest standards of data privacy, data security, as well as risk and quality management.

Approved for clinical use

MH Guide/Mendel is a module of MH Guide, a software application approved in Europe as an IVD medical device (according to Directive 98/79/EC).

SaaS – individually scalable

MH Guide/Mendel is offered as scalable SaaS (Software as a Service) to suit small and large institutions alike.

Customizable patient reports

The design, content, and format of analysis reports can be adapted to individual needs on request.

Flexible input and output formats

MH Guide/Mendel can process the standard data formats VCF and FASTQ. Output formats are PDF, JSON, and XML.

Secure data transmission

MH Guide/Mendel provides secure transmission of patient data through advanced encryption standards (SSL/TLS, AES-256) and storage of patient data with controlled access authorization.

Guaranteed security of patient data

MH Guide/Mendel complies with GDPR in Europe, GenDG in Germany, and the Health Insurance Portability and Accountability Act (HIPAA) in the USA.

Efficient workflows in your laboratory

MH Guide/Mendel lets you optimize your everyday processes. The cloud-based software automates the interpretation of germline variants and delivers high-quality analyses.

Intuitive report generation in just a few steps

MH Guide/Mendel intuitively guides users from data upload to final patient report.

1. Upload sequence data to the MH Order Portal – via your browser


2. Automatic variant classification

MH Mendel - 2. Preclassified variant_Kontur

3. Creation of the report

MH Mendel -3. Report Erstellung_Kontur

4. Export of the report

MH Mendel - Sample Report-1_Kontur
Dr. Daniel Kritsch

Dr. Daniel Kritsch
Senior Application Specialist – Scientific Field Support

“MH Guide/Mendel supports you in efficiently performing high-quality germline analyses – even at high testing volumes. We would be happy to demonstrate how you can use MH Guide/Mendel to meet your individual requirements. Just contact us.” 

Our additional solutions for supporting clinical routine

From sequencing data to patient reports in a few minutes

MH Guide identifies and interprets genetic variants in tumors quickly while also ensuring quality. The MH Guide Report supports practitioners in the selection of treatment options and clinical studies that match the molecular profile of cancer patients. MH Guide is an IVD medical device approved in the EU.

Find out more

Software-supported analysis of hereditary predisposition to breast and ovarian cancer syndrome (HBOC)

MH Guide/BRCA supports human geneticists in the identification of clinically significant germline variants associated with hereditary breast and ovarian cancer syndrome (HBOC). NGS based analyses of BRCA1/2 and other HBOC related genes are automatically evaluated.

Find out more


MH Guide/Mendel generates well-designed, adaptable report templates in various formats (PDF, JSON, XML) and can process FASTQ and VCF data formats.

MH Guide/Mendel, like MH Guide, fulfills the highest standards in terms of data privacy and data protection, as well as risk and quality management. MH Guide/Mendel uses and processes data only with the consent of the user or the patient. Data sovereignty always lies with the user. Confidential patient data is transmitted using advanced encryption standards (SSL/TLS, AES-256).

This depends on your requirements. Prices are calculated based on the number of analyses and the size of the gene panels to be analyzed. We are happy to advise you personally.

MH Guide is the main software application, MH Guide/BRCA and MH Guide/Mendel are special modules. You can find more information here: MH Guide and MH Guide/BRCA.

You can use any commercially available or proprietary gene panels (small or large) and have the data analyzed in VCF format with MH Guide/Mendel. Likewise, Whole Exome Sequencing (WES) data can be analyzed. In addition, MH Guide/Mendel can analyze data from other sample assays if detected variants are uploaded in VCF format. MH Guide/Mendel can also process and analyze raw data (FASTQ) from many popular Illumina platforms. Molecular Health can assist with the annotation of gene variants from whole-genome sequencing (WGS) analyses upon request.

Yes, you can assign case-related accounts and rights, giving clinical colleagues access to the discussed case.

On request, Molecular Health can assist you in transferring ACMG-compatible variant classifications as well as genotype-phenotype correlations and descriptions from your own databases to your account.

Do you have special requests, or would you like more details about MH Guide/Mendel?

Give us a call or send us an e-mail

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