Hereditary cancer predisposition analysis of breast and ovarian cancer syndrome (HBOC)
Molecular Health Guide BRCA (MH BRCA) supports medical professionals in identifying and reporting clinically significant germline variants associated with hereditary breast and ovarian cancer (HBOC) syndrome from NGS-based assessment of BRCA1 and BRCA2 and other HBOC related genes. MH BRCA is part of the Molecular Health Guide (MH Guide) solution which is an IVD registered in the EU.
Knowing the risk for HBOC can mean early detection and prevention
MH BRCA is a diagnostic support software for analysis of HBOC-related genes, in particular BRCA1 and BRCA2, for use by clinical labs, molecular pathologists, and human geneticists. The application analyzes genetic data from a patient’s sample, focusing on germline variants detected from Molecular Health’s integrated databases and world-standard reference sources and preclassified using ACMG classification criteria. Medical professionals can generate standardized diagnostic reports for individual patients, efficiently and accurately.
Highly-automated report creation
From raw data to a well-designed report in a few clicks
Focus on clinically significant variants
Automatic pre–classification using ACMG criteria
Approved for clinical use
MH BRCA is part of MH Guide which is registered as an IVD medical device in the EU. lt is subject to a stringent quality process, so you can rely with confidence on the results.
World-class knowledge database
Molecular Health gathers and structures information from multiple external sources, so users can access regularly updated information on population frequencies, functional impact predictions, variant classifications, and variant-disease correlation.
Convenient ordering process
Benefit from MH’s user-friendly ordering application, MH Order portal, for ordering analyses, uploading NGS data, and tracking orders.
Certified dry lab
Molecular Health has been CAP- and CLIA-certified since 2016, the first international bioinformatics dry laboratory to achieve this milestone.
Certified operational quality
Molecular Health’s quality management system is ISO 13485 and MDSAP certified and CLIA/CAP accredited.
For clinical use
MH BRCA is a subcomponent of the IVD medical device MH Guide in Europe (according to Directive 98/79/EC).
The application is provided as a Software as a Service (SaaS), so you benefit from standard operating procedures.
Secure data transmission
Secure transmission of patient data using advanced encryption standards (SSL/TLS, AES-256).
Scalable IT infrastructure to suit a range of labs, from smaller units to high throughput organizations.
MH BRCA can process standard sequencing data formats, including VCF and FASTQ. Output formats include PDF, json, or XML.
Guaranteed patient data security
MH Guide meets the requirements of HIPPA in the US and the BDSG and GenDG in Germany.
Ethnicity-specific variant information
Sequencing alignment using ancestry- or ethnicity-specific reference genomes.
More of our powerful applications for decision support
Molecular Health Guide Mendel (MH Mendel) supports human geneticists to identify clinically significant genetic variants and create a diagnostic report for individual patients. MH Mendel is part of the Molecular Health Guide (MH Guide) solution which is an IVD registered in the EU.
Molecular Health Guide (MH Guide) identifies safe and effective therapies for patients by analyzing the molecular profile. It matches detected mutations to the world’s knowledge in the field of oncology and hereditary diseases and helps medical experts to create a patient-specific clinical report. MH Guide is an IVD registered in the EU.
Let’s talk about how our technology can work for you
To find out more, you can call our customer care team or help desk or send us an e-mail. We would be delighted to provide you with more information or answer your questions.