Hereditary disease analysis
MH Mendel supports human geneticists to identify clinically significant genetic variants and create a diagnostic report for individual patients. MH Mendel is part of the Molecular Health Guide (MH Guide) solution which is an IVD registered in the EU.
Accelerate the assessment of germline variants
MH Mendel is a hereditary disease diagnostic support software for clinical labs, molecular pathologists and molecular geneticists. The application analyzes complex genetic data from a patient’s sample and matches the results to knowledge in Molecular Health’s integrated databases and world-standard reference sources. Variants identified as relevant for a diagnosis are pre- classified so that medical professionals can generate standardized diagnostic reports, efficiently and accurately.
Approved for clinical use
MH Mendel is part of MH Guide which is registered as an IVD medical device in the EU. MH Mendel is subject to a stringent quality process, so you can rely with confidence on the results.
Certified dry-lab
Molecular Health has been CAP- and CLIA-certified since 2016, the first international bioinformatics dry laboratory to achieve this milestone.
Automatic variant classification
Benefit from automated variant pre-classification using standard ACMG terminology to focus on relevant information at a glance.
Unlock knowledge at the genomic level
View genotype-phenotype correlations
Extendable knowledge base
Grow your organization’s knowledge base, as variant classifications are added with every case and immediately available for all colleagues.
Flexible report generation
Generate a diagnostic report using a well-designed standardized template in just a few clicks. If wished, refine the report contents, include additional test results, and type an interpretation. Report layouts are customizable on request to suit the customers’ needs.
Increase report creation speed
Gene and variant filters can help medical professionals to identify disease-related variants faster.
Easy to integrate
Integrate the analysis smoothly into existing processes: MH Mendel’s flexible interface can analyze a range of standard sequencing data formats.
Consultation with colleagues
Easily share a case with a colleague to get a second opinion.
Convenient ordering process
Benefit from MH’s user-friendly ordering application, MH Order portal, for ordering analyses, uploading NGS data, and tracking orders.
World-class knowledge database
MH gathers and structures information from multiple external sources, so users can access regularly updated information on population frequencies, functional impact predictions, variant classifications, and variant-disease correlation.
For clinical use
MH Mendel is a subcomponent of the IVD medical device MH Guide in Europe (according to Directive 98/79/EC).
SaaS
The application is provided as a Software as a Service (SaaS). A standard PC with internet access is sufficient.
Certified operational quality
Molecular Health’s quality management system is ISO 13485 and MDSAP certified and CLIA/CAP accredited.
Data storage
Secure, encrypted storage of patient data with controlled access using user private keys.
Secure data transmission
Secure transmission of patient data using advanced encryption standards (SSL/TLS, AES-256).
Scalable
Scalable IT infrastructure to suit a range of customers, from smaller units to high throughput organizations.
Flexible input and output formats
Input formats: choose from VCF, FASTQ or BAM. Output formats: PDF, json, or XML.
Guaranteed patient data security
MH Mendel meets the requirements of HIPAA in the US and the GDPR in Europe as well as the GenDG in Germany.
Ethnicity-specific genome analysis pipeline
Sequencing alignment using ancestry- or ethnicity-specific reference genomes.
Expand your knowledge base
Start building a knowledge base for your organization by storing your variant classifications in MH Mendel and make these available to your organization.
More of our powerful applications for decision support
Molecular Health Guide (MH Guide) identifies safe and effective therapies for cancer patients by analyzing the cancer’s molecular profile. It matches detected mutations to the world’s knowledge in the field of oncology and hereditary diseases and helps medical experts to create a patient-specific clinical report. MH Guide is an IVD registered in the EU.
Molecular Health Guide BRCA (MH BRCA) supports medical professionals in identifying and reporting clinically significant germline variants associated with hereditary breast and ovarian cancer (HBOC) syndrome from NGS-based assessment of BRCA1 and BRCA2 and other HBOC related genes. MH BRCA is part of the Molecular Health Guide (MH Guide) solution which is an IVD registered in the EU.
Let’s talk about how our technology can work for you
To find out more, you can call our customer care team or help desk or send us an e-mail. We would be delighted to provide you with more information or answer your questions.
