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Every patient is unique – and your cancer treatment should be unique too.

How you can work with your oncologist and the Molecular Health Guide (MH Guide) software to identify the appropriate drug-based treatment option for you.


Every patient is unique – and your cancer treatment should be unique too.

How you can work with your oncologist and the Molecular Health Guide (MH Guide) software to identify the appropriate drug-based treatment option for you.

Where medicine is today

The guidelines physicians use when they prescribe medications are general recommendations which are based on analyses of specific patient groups and cancer types. In other words, cancer patients are given treatment that is tailored to the disease itself but not to the individual patient, the exact biology of the tumor or any patient-specific traits. This means that the ideal medicine is not always selected in every case.

In the meantime, a big step forward and progress has been made as research has begun integrating genetic data about individual patients into the process of making decisions about medication. Genetic mutations which cause cancer and are responsible for its growth are the point of departure for exactly this kind of personalized treatment.


Access to customized treatment can make a difference for you 

Cancer is an abnormal growth of cells. Cancer cells divide faster and more frequently than healthy cells. They reproduce on an uncontrolled basis, creating a mass of mutated cells. These malignant masses expand into surrounding healthy tissue and consume it. From wherever they originate, they can spread to other organs through the blood or vascular system, and they reproduce elsewhere in the body as metastases.1

Changes in DNA — in our genetic material — can cause cancer. And this is where the challenge lies: since our DNA is unique, every cancer is different.  

1 Source:
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Using MH Guide for customized cancer treatment

The MH Guide software is a medical device registered throughout Europe. It offers your oncologist a unique form of support in finding the right medication for “your” cancer — medicine that is effective and has as few side effects as possible.

Your tumor sample is sequenced in a special laboratory.

The data obtained from sequencing are compared with the database in the MH Guide product.




Your treating physician receives a medical report from the MH Guide-certified physician which serves as the basis for a personalized therapeutic decision.

Which patients are good candidates for a MH Guide analysis?

In general, all solid tumors and blood cancers can be analyzed. The tumor specimen has to meet particular criteria in terms of its quantity and quality. Analyses tend to be especially interesting for patients who have exhausted standard therapies because their disease has reached an advanced stage or because they may benefit from participating in an appropriate clinical trial. A number of different substances are currently being tested in clinical trials to determine their efficacy.

Answers to other frequently asked questions can be found here

How you can benefit from an analysis with MH Guide

You will receive:

Precise individual treatment options for your personal situation

The direct path to a more effective drug-based cancer treatment with fewer side effects — from the very beginning
Access to the latest medical developments  
Information about any clinical trials that may be relevant for you  
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Molecular Health Button
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Molecular Health Button

How you can benefit from an analysis with MH Guide

You will receive:

Precise individual treatment options for your personal situation  
Molecular Health Button
The direct path to a more effective drug-based cancer treatment with fewer side effects — from the very beginning  
Molecular Health Button
Access to the latest medical developments  
Molecular Health Button

Information about any clinical trials that may be relevant for you


Molecular Health Button

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The step-by-step procedure for receiving customized cancer treatment

Your treating physician will talk to you about the option of an MH Guide analysis in your particular case.

Your treating physician will contact an MH Guide-certified physician. They will resolve any open questions and discuss the next steps in preparing the analysis.

Preparing the analysis

Your doctor is sent all of the relevant information and forms needed to prepare the analysis.

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The MH Guide-certified physician works with the treating physician to arrange the necessary tumor samples. The samples are then further processed and analyzed to obtain data.

Your treating physician will discuss the findings and therapeutic options with you as well as talking about potentially enrolling in a suitable clinical trial.

After the genetic examination of the samples (DNA sequencing) and the subsequent analysis by MH Guide, a medical report is issued based on the findings. This medical report is created and issued by a MH Guide-certified physician who will communicate the findings to your treating physician to support him or her in selecting customized treatment.

Your treating physician will discuss the findings and therapeutic options with you as well as talking about potentially enrolling in a suitable clinical trial.

Who pays for an MH Guide analysis?

Depending on country-specific regulations and on the cancer entity, an MH Guide analysis and the underlying NGS assay is reimbursed. Reimbursement is either a standard or initiated per additional extra request. If it is not reimbursed, you may want to cover the costs by yourself. 

Please contact us for more information: 

Protecting your personal data is a critical issue in our eyes
Both self-paying and reimbursed patients or those whose employers offer the Corporate Oncology Program for Employees (COPE) can rest assured that none of their personal information is communicated to the company. Only the treating physician and the MH certified physician have access to personally identifying patient data. Molecular Health works exclusively with pseudonymized data; no personal information is conveyed or saved.
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The process of linking information about sequencing to information about those genes.

A substance or biological characteristic in the tumor tissue, blood or other bodily fluid that can be identified via test procedures and used to diagnose or monitor cancer or assess the response to treatment.

A malignant tumor of the epithelium (skin tissue or lining of an organ).

Also called clinical studies. Clinical research conducts carefully structured tests to determine the safety and efficacy (=effectiveness) of drugs, medical devices, diagnostic processes and approaches to treatment.

Deoxyribonucleic acid. A cellular macromolecule that carries genetic information.

The process of determining the order of the nucleotides in a DNA molecule.

Supported by a large amount of research that confirms the findings.

The process in which genetic information is used to form proteins.

A simple set of a cell’s chromosomes that makes up its genetic material.

The entirety of a living being’s genetic factors.

“An in-vitro diagnostic (IVD) tool is any medical device which is designed by the manufacturer for use in in-vitro examination of specimens taken from the human body, including blood and tissue samples, and used exclusively or primarily to determine certain information. An IVD can be a reagent, reagent product, calibration material, control material, kit, instrument, apparatus, device or system used alone or combined with other such devices.”

Usually, after an effective first-line treatment, a pause in therapy is scheduled so the body can regenerate from the effects of the medicines. If, however, the first-line treatment does not have the intended effects — if the tumor has reacted only slightly, if at all, and the symptoms have not improved — the physician can prescribe maintenance therapy. In doing so, the doctor switches to another drug to achieve the same effect (that is, shrinking the tumor). Maintenance therapy begins immediately after first-line treatment with no pause in between.

Medical devices are products the manufacturer designs for a medical purpose and for human use. Unlike drugs, which have an effect that is pharmacological, immunological or metabolic, medical devices when used as intended usually achieve their effect through a physical route.

An approach to high throughput sequencing. This is an optimization of standard sequencing technologies. NGS enables researches to decode major amounts of DNA within a very short time. The most advanced sequencing devices of this generation are able to create corresponding amounts of data within a single sequencing process. This means entire genomes can be decoded quickly.

A spontaneous or externally created change in genetic material.

The use of prescription medications for a purpose other than the one which was officially approved.

A gene that can transform a cell into a tumor cell under certain circumstances.

An analysis of the genes that may be relevant in treating cancer. This involves more than 500 genes.

Treatments which are customized to the individual needs of patients and based on information taken from different biomarkers.

Pharmacovigilance is the process of ongoing and systematic monitoring of a finished medical product’s safety in human or animal use. The objective is to identify any adverse effects, assess them and interpret them so that the appropriate measures can be taken to minimize risk.

A predictive biomarker makes it possible to estimate how well the patient will respond to a particular treatment, and it assists physicians in selecting the best possible form of therapy.

The number of patients who react to treatment.

A malignant tumor in connective tissue.

A (tissue) sample.

The different phases of treatment which are administered in a certain order are known as first-line and second-line treatments. In some cases, a period of maintenance therapy takes place between these two phases.

“Recurrence (from the Latin for “falling back”) is the return of a disease, a psychological disorder or related symptoms after a treatment which was temporarily effective or after spontaneous remission. In the context of cancer treatment, recurrence usually happens because the tumor was not completely removed, and after a certain period, this can cause the disease to come back.
If there has been no recurrence in the five years after treatment, the patient is generally considered to be cured. However, some tumors can cause recurrence much later than that.”

A tumor classification system that was created by the Union Internationale Contre le Cancer.

An analysis of all of the transcribed regions of the human genome. It includes over 20,000 genes.

Molecular Health Guide (MH Guide) can be used to analyze every kind of cancer, i.e. both solid tumors and hematologic malignancies, such as leukemia. Analyses with MH Guide are considered especially useful for patients with rare forms of cancer as well as cases in which the cancer has metastasized (spread to other organs) or in which previous treatment regimens had limited or no success. 

The entire processing period takes around four weeks for sequencing both the genetic panel (approximately 600 genes) and whole exome sequencing (approximately 20,000 genes). This covers the entire period from when the sample arrives at the laboratory to the time when the report is sent to the treating physician, and it includes genome sequencing, data processing, and generating the report.  

Molecular Health Guide (MH Guide) provides information about the presence or absence of certain mutations in the patient’s tumor or the control sample. Furthermore, potentially relevant clinical and scientific data as well as information about the reliability of the findings are made available for physicians to include in their assessment. 

The data about the mutations that have been identified do not lead to clear-cut clinically actionable findings in every case, since genetic changes cannot always be directly linked to a potentially effective therapeutic option. For example, there may not be clear-cut information if there is not enough clinical evidence of a mutation or if the reliability of the findings is not robust enough due to quality problems with the sample. 

As a rule, the process of analyzing the genetic variants in a tumor has shown to be a valid approach to gaining more insight into the nature of an individual patient’s cancer. This helps the specially trained physicians and treating physicians make therapeutic decisions with greater precision. MH Guide provides access to high-quality biomedical reference data in great depth so that our specially trained doctors have an optimal foundation of evidence for clinically interpreting mutations in cancer patients. 

In the course of analyzing genetic data via Molecular Health Guide (MH Guide), the physicians may discover information about genetic changes which are not directly related to the cancer diagnosis that was the reason for the analysis, but the information may nevertheless be of medical relevance to you and your family. This kind of additional information is known as incidental findings. The physicians who work with MH Guide are not actively looking for such findings. If, however, they come across something that indicates a preventable or curable disease, they can communicate this information to a genetic specialist if you wish. 

Any incidental findings involving genetic diseases that are not relevant to your cancer can be discussed in a consultation with the genetic specialist. In the informed-consent declaration, you can indicate whether you wish to be informed about any such findings. 

Molecular Health uses your samples for the genetic analysis of your tissue specimens. Furthermore, if you have given your consent, they may also be used for quality-control purposes. 

You have the right to refuse a genetic analysis from the outset. Once a genetic examination has begun, you still have the right to remain uninformed about some or all of the results, or even to have all of the related information deleted.  You can contact your physician to withdraw your consent to the analysis at any time, verbally (by telephone) or in writing, and do not need to provide any further reasons.  You have the right not to be informed about the results of the analysis (the right not to know). In addition, you also have the right to stop the ongoing examination process at any time up until the results are communicated to you, and to demand the destruction of materials as well as of results which have already been obtained at that point in time.  Please note that subsequent inquiries about the findings will then be no longer possible. 

When a Molecular Health Guide (MH Guide) analysis is ordered, histological and other routine diagnostic information about your disease should already have been collected. For most patients, enough of a tumor sample has already been taken and stored, and it is thus available without any further medical intervention at the time of the MH Guide analysis. Should additional material or blood samples be required for the analysis, your physician will speak to you about it and inform you of any possible related health risks. 

Genetic data can contain information about whether you have an inherited predisposition to certain diseases. This can also affect your family members and confront you with a new situation. 

Furthermore, there is a very slight chance of identifying someone by their genetic characteristics, but this risk is extremely low.  This risk only exists in the unlikely event that the patient published their own genetic data online at an earlier time (e.g. for genealogy purposes) and that an unforeseen data breach accidentally made Molecular Health information available to a third party. The security measures implemented for MH Guide comply with the state of the art and are designed to rule out the misuse of data. Any misuse of patient data is a punishable crime. 

Both the MH-Guide-certified physician and treating physician are bound by medical confidentiality, although they may communicate with each other. This is necessary so that they can discuss the indication and stage of the illness, co-medication as well as any clinical information necessary for the ideal therapeutic decision. 

The law states that you have to give your consent before a procedure is performed. This ensures that you were given enough information about the procedure and understand what it involves. By signing the document, you confirm this and agree to have the genetic analysis conducted.   

Let’s talk about how our technology can work for you

To find out more, you can call our customer care team or help desk or send us an e-mail. We would be delighted to provide you with more information or answer your questions.

EU: +49 6221 43851-150