Quality-assured interpretation of complex genetic data

For the growing challenges of today and tomorrow

CE-in-vitro diagnostic software solutions for your data interpretation

Growing data volumes, constantly increasing biomedical knowledge, more complex analytical procedures, and databases that are insufficiently standardized – these are just some of the challenges that molecular pathology and diagnostic laboratories face. In addition, there is time pressure and increasing demands on data interpretation, for example in molecular tumor boards. Our software solutions help you master these challenges more easily.

Better and faster results

With MH Guide, we have developed in-vitro diagnostic software that allows the analysis of genome variants in comparison with the latest scientific findings – efficiently, precisely, and in line with your requirements. MH Guide helps you interpret data and collaborate directly with clinical colleagues.

Precision oncology demands precision pathology

When suitable for patients, precision medicine is increasingly the first-choice cancer treatment. This places increasing demands on molecular pathology and diagnostic laboratories, since targeted cancer therapies require precision pathology to identify appropriate biomarkers in tumor material or liquid biopsy.

MH Guide enables automated gene variant interpretations from small and large panels for evidence-based results with high quality – even at high testing volumes.

Big data analysis for laboratories – automated variant interpretation via “learning database”

MH Guide, one of the first CE-marked IVD medical devices for molecular diagnostics, compares your NGS test results with relevant biomedical knowledge from current research. To do this, the software draws on one of the world’s largest knowledge bases, Dataome, which continuously processes published biomedical knowledge along with information about drugs and current clinical trials.

MH Guide summarizes the results of this analysis in an informative report, your ideal tool for helping oncologists come to decisions on targeted treatment.

The modules MH Guide/BRCA and MH Guide/Mendel are specifically tailored to the diagnosis of hereditary breast and ovarian cancer syndrome (HBOC) and the needs of human geneticists, respectively.

MH Guide includes a validated process for analyzing NGS data that delivers evidence-based results quickly and comprehensively. This helps your lab increase the quality of result interpretations and simplify report generation – so you are well-equipped to manage all present and future demands that precision medicine entails.

Discover here: the future of automated variant annotation


Mit dem Laden des Videos akzeptieren Sie die Datenschutzerklärung von YouTube.
Mehr erfahren

Video laden

How your laboratory benefits

Cloud-based portal

Fast login and quick access to the latest platform version

Rapid results

High-speed clinical annotation and report creation

Simple upload

Easily upload files via encrypted connections


Our annotations undergo a rigorous review process


Data processing in accordance with GDPR, state-of-the-art encryption


Review as many variants as you find useful


Accepts standard file formats from any analysis method


Single and volume pricing available

The workflow of MH Guide

How your lab benefits:

Efficient, high-quality results

“Increasingly, larger panels are playing a role in molecular testing and variant interpretation. Automated interpretation tools like MH Guide ensure fast and accurate results.”  

We have put together a brochure for you to find out more about the benefits and functionality of MH Guide.

PD Dr. med. Christian Meisel
Chief Medical Officer


We would be happy to offer you a software demo. Send us your request in writing or call us: +49 6221 43851-150.

MH Guide can process FASTQ and VCF data and offers pathologists highly-automated generation of individual patient reports, each of which can be expanded and refined, including results from non-NGS methods (FISH, IHC, (q)PCR). The software generates well-designed, adaptable report templates in various formats (PDF, JSON, XML).

MH Guide fulfills the highest standards in terms of data privacy and data protection, as well as risk and quality management. Data sovereignty always lies with the user. Confidential patient data is transmitted and stored using advanced encryption standards (SSL/TLS, AES-256).

This depends on your requirements. Prices are calculated based on the number of analyses and the size of the gene panels to be analyzed. We are happy to advise you personally.

MH Guide is the main software application, MH Guide/BRCA and MH Guide/Mendel are special modules. You can find more information here: MH Guide, MH Guide/BRCA, MH Guide/Mendel.

You can use any commercial or proprietary gene panel (small or large) and have the data analyzed in VCF format with MH Guide. Likewise, whole-exome (WES) and whole-genome (WGS) data can be analyzed with MH Guide. Raw data (FASTQ) from gene panels and WES analyses from popular Illumina platforms can be analyzed using MH Guide Premium.

MH Guide allows users to maintain and edit their own annotation data and variant classifications in a personal, secure account area. On request, Molecular Health can assist you in transferring ACMG-compatible variant classifications and descriptions from your own databases to your account.

Yes, you can assign case-related accounts and rights, giving clinical colleagues access to the discussed case.

Our software solutions for the optimal support of laboratory decisions

From sequencing data to patient report – in just minutes

MH Guide quickly and accurately identifies and interprets genetic variants in tumors. The MH Guide report helps treatment providers choose therapy options and clinical trials that match the cancer patient’s molecular profile. MH Guide is an IVD medical device approved in the EU.

Find out more

Software-assisted analysis of predisposition to hereditary breast and ovarian cancer syndrome (HBOC)

MH Guide/BRCA supports human geneticists in identifying clinically-significant germline variants associated with hereditary breast and ovarian cancer syndrome (HBOC). This involves automated NGS-based analysis of BRCA1/2 and other HBOC-related genes.

Find out more

The automated analysis of hereditary diseases

MH Guide/Mendel helps human geneticists evaluate NGS-based analyses by automatically identifying clinically-significant genetic variants for hereditary diseases.

Find out more

Dr. Katrin Stecker
Head of Scientific Field Support

“We are working to identify clinically-relevant gene variants as efficiently and reliably as possible. Our goal is to give you the best possible support for your daily analyses and your research projects.”

Contact form

Many Thanks!

Your request was successfully sent.