Predict success.
With AI.

Molecular Health Predict (MH Predict) is an application designed to predict clinical trial probabilities of success using the latest developments in Artificial Intelligence (AI) and Machine Learning (ML).

Transparency is the foundation of trust in AI/ML algorithms. Users need to know what data the algorithms consider, and what thresholds are used in arriving at the conclusions, so that they can understand the results and reap the benefits AI offers with confidence. This is especially true for applications used in a medical context. MH Predict creates trust by providing customers access to AI/ML algorithms in an easy and intuitive way.

MH Predict is an AI software...

...that draws curated biomedical data from numerous sources to:

  • predict technical success of clinical trials
  • identify potential success or failure factors for clinical trials

...that predicts clinical trial success with high accuracy and has the following benefits:

  • Provides a complementary and unbiased assessment of probability of success
  • Materially de-risks R&D and budget decision-making
  • Increases the certainty of portfolios by identifying the programs most likely to succeed
  • Provides further guidance on M&A and licensing decisions
  • Supports competitive intelligence by unbiased prediction of competitor's portfolio or trial performance
  • A market-facing tool to give investors confidence in capital allocation in R&D and pipeline

Video: MH Predict overview

MH Predict's value to R&D and commercial Pharma functions

MH Predict clinical trial case

  • Trial point prediction (success/failure)
    • Probability of technical success
    • Reliability graph
  • Contextualization: compare the prediction to similar trials
  • Feature effect simulation (in the UI, more detailed analysis offered ex-UI)
  • Feature importance analysis - opening the black box by identifying key parameters influencing the prediction (offered ex-UI)

Probability of trial success predicted by MH Predict relates to the real-world outcomes of clinical trials.

REQUEST DEMO

Please fill your contact details below:

I agree that my name, email address, and any other information I provide, can be transferred to Molecular Health GmbH and processed there for the purpose of answering my request. I have read the privacy policy and hereby agree that my personal data may be processed as described. I can revoke this agreement at any time.

News

23

FEB 2019

Plattform Life sciences

Editorial: Predicting clinical trial success and improving R&D

12

FEB 2019

Transkript

A banker with an idea (in German)

01

FEB 2019

Handelsblatt

DIGITALISIERUNG UND GESUNDHEIT
Die Medizin der Zukunft - Wie uns KI vor Krebs und Herzinfarkt schützt (in German)

31

JAN 2019

BioIT World

Molecular Health announced that it has granted an exclusive license to DATEN CAPITAL to apply MH Predict to the financial markets.

20

JAN 2019

PMWC 2019

Panel with Armin Schneider, Applying Machine Learning to Predict Drug Development Success session.

Panel with Armin Schneider, Applying Machine Learning to Predict Drug Development Success session presented at PMWC 2019

FAQs

What problem does MH Predict address in the pharma/biotech space?
Drug discovery and development are long, costly, and inefficient. The average costs of bringing a drug to market have risen to US$2.6bn, according to the latest analysis by DiMasi and colleagues of Tufts University (DiMasi JA, Grabowski HG, Hansen RW. Innovation in the pharmaceutical industry: new estimates of R&D costs. Journal of Health Economics 2016; 47:20-33.), mostly owing to an attrition rate of 11 failed projects for every successful one. AI now offers opportunities to improve this process at virtually every stage.
What are Machine Learning (ML) and Artificial Intelligence (AI)?
ML is a well-defined term that describes a number of computational methods (algorithms) that allow a computer program to learn from data without specific instructions and improve learning with more data ("experience"). Computer scientist Tom Mitchell came up with the most famous and clear-cut definition: "A computer program is said to learn from experience E with respect to some class of tasks T and performance measure P if its performance at tasks in T, as measured by P, improves with experience E." ML is therefore a purely technical term. In contrast, AI is not as clearly defined. AI pertains to a concept rather than a method. There are points of contact with psychology, computer science, philosophy, biology and neuroscience. AI uses ML as a method, but solutions can also be created by non-ML systems, for example, knowledge systems. AI integrates ML into solutions. An autonomous car is an example of AI, with one component being ML algorithms. ML is thus a subset of AI. However, ML as a method has been the biggest contributor to the growing success of AI in recent years. In this sense, MH Predict can be referred to as both ML and AI.
How are AI/ML used in the drug development world?
ML applications are now being tried in virtually all steps of the drug discovery/development cycle and post-marketing to improve drug adherence. According to the Financial Times, in 2018 at least 15 big pharma and biotech companies used AI in parts of their drug development cycle. Most examples of the use of AI in pharma come from early drug discovery (target discovery, lead compound identification) or lead optimization, fields that have previously used quantitative approaches and statistical modelling. Progress in pattern recognition in pathological or radiological images and sensor signals opens up new opportunities for biomarker discovery for use in clinical trials (e.g., patient inclusion or endpoint definition).

AI is now also moving into the area of clinical operations with systems that optimize patient recruitment and site selection. MH Predict sits at the clinical stage of the drug development path but extends into the earlier translational space and strategic and business aspects within pharma.

Examples of usage and AI/ML deals in the drug development process include:

  • Target discovery
  • Lead compound identification
  • Lead optimization/medicinal chemistry
  • Patient selection
  • Prediction of clinical success
  • Clinical operations

If you can not find the answer to your question, please contact us

Events

29 MAR

03 APR

AACR

City: Atlanta

8-10

APR 2019

World Medical Innovation Forum – Al

City: Boston

3-6

JUN 2019

BIO

City: Philadelphia

12-13

JUN 2019

Al Summit London

City: London

23-24

SEP 2019

Annual Drug Repositioning Conference

City: Washington