MH Mendel | Molecular Health

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Hereditary disease analysis

MH Mendel supports human geneticists in diagnosing hereditary diseases and creating diagnostic reports for individual patients. The germline data analysis follows official genetic guidelines and uses ACMG variant classification criteria.

Accelerate the assessment of germline variants

MH Mendel is a hereditary disease diagnostic support software for clinical labs, molecular pathologists and molecular geneticists. The application analyzes complex genetic data from a patient’s sample and matches the results to knowledge in Molecular Health’s integrated databases and world-standard reference sources. Variants identified as relevant for a diagnosis are pre- classified so that medical professionals can generate standardized diagnostic reports, efficiently and accurately.

Certified dry-lab

Molecular Health has been CAP- and CLIA-certified since 2016, the first international bioinformatics dry laboratory to achieve this milestone.

Automatic variant classification

Benefit from automated variant pre-classification using standard ACMG terminology to focus on relevant information at a glance.

Unlock knowledge at the genomic level 

View genotype-phenotype correlations 

Extendable knowledge base

Grow your organization’s knowledge base, as variant classifications are added with every case and immediately available for all colleagues.

Flexible report generation 

Generate a diagnostic report using a well-designed standardized template in just a few clicks. If wished, refine the report contents, include additional test results, and type an interpretation. Organizations can customize the layout to suit their needs.

Increase report creation speed

Gene and variant filters can help medical professionals to identify disease-related variants faster.

Easy to integrate

Integrate the analysis smoothly into existing processes: MH Mendel’s flexible interface can analyze a range of standard sequencing data formats.

Consultation with colleagues

Easily share a case with a colleague to get a second opinion.

Convenient ordering process

Benefit from MH’s user-friendly ordering application, MH Order portal, for ordering analyses, uploading NGS data, and tracking orders.

World-class knowledge database

MH gathers and structures information from multiple external sources, so users can access regularly updated information on population frequencies, functional impact predictions, variant classifications, and variant-disease correlation.

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The application is provided as a Software as a Service (SaaS), so you benefit from standard operating procedures.

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Certified operational quality

MH’s quality management system is ISO 13485-certified and the software design process is IEC 62304 and ISO 14971-certified.

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Data storage

Secure, encrypted storage of patient data with controlled access using user private keys 


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Secure data transmission

Secure transmission of patient data using advanced encryption standards (SSL/TLS, AES-256)

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Scalable IT infrastructure to suit a range of labs, from smaller units to high throughput organizations

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Flexible input and output formats

Input formats: choose from VCF, FASTQ, BAM, or XML. Output formats: PDF, json, or XML

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Guaranteed patient data security

Meets the requirements of HIPPA in the US, guaranteeing the highest levels of patient data security (HIPPA: Health Insurance Portability and Accountability Act).

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Ethnicity-specific variant information

The MH-developed genome analysis pipeline preserves ethnicity-specific variant information using ethnicity-specific reference genomes

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Flexible hosting

Flexible hosting, on local servers, with all client data locally stored

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Expand your knowledge base

Import your existing variant classification information and start building a knowledge base for your organization

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Let’s talk about how our technology can work for you

To find out more, you can call our customer service or send us an e-mail. We would be delighted to provide you with more information or answer your questions.